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Common Rybelsus side effects reported in clinical trials include: Nausea Abdominal pain Diarrhea Decreased appetite Vomiting Constipation [2] If any symptoms become severe or concerning, contact your healthcare provider

March 19, 2026: Eli Lilly announced TRANSCEND-T2D-1 topline results in adults with type 2 diabetes

You have conditions or medications where oral absorption could be unreliable

Clinical trials show that nausea improves after 48 weeks regardless of caffeine consumption, suggesting caffeine mainly affects tolerability rather than therapeutic outcome

Why You Need To Work With A Doctor When Youre On GLP-1 Medications Obesity is a complicated condition

You experience significant side effects : Persistent nausea, vomiting, diarrhoea, or abdominal discomfort should be reported, particularly if these symptoms interfere with nutrition, hydration, or quality of life