Shiraki and colleagues determined that GLP-1 agonists anti-inflammatory effect were particularly robust on vascular endothelial cells [56]
This promotes reduced contraction and increased relaxation of many parts of the gastric system, including the antrum of the stomach
For other formulations, the general guideline is to take Janumet with meals to maximize absorption and reduce the likelihood of gastrointestinal side effects
According to the SmPC, patients should be monitored regularly during Saxenda treatment, with particular attention to gastrointestinal tolerability and heart rate
Starting at lower doses and increasing according to product-specific schedules (ranging from 1-4 weeks depending on the agent) allows physiologic adaptation
However, some patients have reported experiencing leg discomfort, restlessness, or twitching after starting or increasing the dose of Mounjaro