weight regain and cardiometabolic effects after withdrawal of semaglutide PDF) semaglutide: The STEP 1 trial extension Semaglutide Alternatives for Weight Loss

While further research is needed to confirm these effects, the current literature supports the potential utility of GLP-1RAs in IIH management

Since 2019, there has been a 1,500% spike in poison center reports involving GLP-1 medications like Ozempic, with 1,678 cases already reported in 2025

Potential benefits of combining intermittent fasting and GLP-1 medications Pairing intermittent fasting with GLP-1 medications may offer several synergistic benefits: Enhanced weight loss: Both approaches reduce appetite and calorie intake, potentially leading to faster and more sustainable weight loss

Severe insulin resistance associated with conditions like non-alcoholic fatty liver disease (NAFLD) or metabolic syndrome may require higher semaglutide doses or combination therapy to overcome

Supplementary information Legends of Supplementary Tables 112

Trim and Fill imputed three missing studies, shifting the effect size downward and highlighting a likely overestimation of treatment effects due to bias