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In physiological conditions, astrocytes play key housekeeping roles offering structural, metabolic, and trophic support to motor neurons [65]

Sheinboim, D

CNS Drugs 6 , 416425 (1996)

The five inhibitors considered in the present investigation are thiamine (vitamin B1 ), pantothenic acid (vitamin B5 ), pyridoxine (vitamin B6 ), Biotin (vitamin B7 ), -tocopherol (vitamin E ), and glutathione ( GSH ), their 2D structures are shown in Fig

It showed also anti-inflammatory properties by downregulating the expression of pro-inflammatory mediators, such as iNOS, COX-2, and TNF-, along with inhibition of the NF-B signaling pathway [75]

Type 1 diabetes is primarily caused by destruction of insulin-producing pancreatic beta cells by autoimmune disease or rarely other causes such as trauma