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Although treatment with each of the three compounds alone was also effective, the combination of chlorogenic acid (CA), neochlorogenic acid (NCA), and cryptochlorogenic acid (CCA) demonstrated the greatest effect on HCECs in the scratch wound-healing assay

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Inactivation of NOX decreases ROS production and prolongs survival in SOD1 G93A mice (Seredenina et al., 2016), and may modify survival in ALS patients (Marrali et al., 2014)

Commercial materials may be supplied as free L-cysteine, L-cysteine hydrochloride anhydrous or L-cysteine hydrochloride monohydrate

(87) found that CB, when combined with Akkermansia muciniphila , synergistically enhances barrier repair and increases sensitivity to anti-PD-L1 immunotherapy

As summarized in Table 4, preclinical and clinical studies support cardioprotective effects of metformin across diverse cardiac conditions, but large, rigorously designed trials are needed to define its role beyond metabolic indications