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Clinical reviews have shown that this transmucosal route successfully bypasses the destructive enzymes of the GI tract and the liver's first-pass metabolism, resulting in a rapid and statistically significant increase in blood GSH concentrations

Brain Res 848:141152

Hou, X., Sang, Y

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Gastrointestinal Function Studies Ipamorelins ghrelin-mimetic properties have been studied in gastrointestinal motility research: Dose-dependent improvement in gastric emptying in rodent postoperative ileus models Enhanced gastrointestinal contractility through cholinergic neuron activation Accelerated recovery of bowel function in experimental surgical models Effects mediated through ghrelin receptor activation in enteric nervous system Phase II human trials investigated ipamorelin for postoperative ileus treatment, though results did not reach statistical significance for primary endpoints