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Compounded drugs differ from FDA-approved generics too, in that FDA does not verify the safety, effectiveness or quality of compounded drugs. For much of this year, the key ingredients across two categories of GLP-1 drugs were designated in shortage: tirzepatide (Mounjaro, Zepbound) and semaglutide (Ozempic, Wegovy)

Only 19% of large employers covered GLP-1s for weight loss in 2025, and many are reducing coverage due to costs

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( Brunetti et al

"Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: A replication study using reports to the World Health Organization pharmacovigilance database (VigiBase)." Journal of Affective Disorders, 2024