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Category D : Covers drugs linked to increased risks of foetal malformations or irreversible damage

Blurred vision: Changes to blood sugar can cause swelling of the lens of the eye, changing its overall shape and causing blurred vision

Dehydration and Kidney Risks The reduced desire to eat and early satiety is accompanied by a decreased thirst signal, putting people taking GLP-1s at risk of experiencing dehydration

Freezer storage (-20 degrees Celsius) Freezing reconstituted peptide can extend usable life to 2-4 months

Diarrhea is a known pharmacological effect of GLP-1 receptor agonist activation in the intestines and does not indicate product quality or efficacy

Maximum Responder Rate (20%+ Loss) CagriSema 60% of CagriSema patients achieved at least 20% weight loss in REDEFINE 1, a higher responder rate than tirzepatide's across-trial data, though cross-trial comparison has limitations