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Heme produces signaling molecules, such as CO, biliverdin (BV), BR and Fe 2+ , through the catalysis of HO-1

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In terms of adverse drug reactions, aggregated data from phase II and III studies indicate that while dotinurad can potentially cause liver-related adverse reactions, such as hepatic steatosis and abnormal liver function tests, which the incidence is lower compared to benzbromarone

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Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial