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Results and Discussion Engineering and Validation of the miniGrx1-roGFP2 Biosensor In our hands, the original Grx1-roGFP2 biosensor displayed somewhat inconsistent performance when fused to various targeting sequences for subcellular localization

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While translational gaps persist, particularly in dosing, timing, and patient stratification, emerging strategies including mitochondria-targeted antioxidants, nanotherapeutics, and biomarker-guided interventions hold promise for restoring redox homeostasis and improving clinical outcomes

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Glutathione deficiency can lower B12 levels because one of glutathiones roles is to protect B12 in the circulation

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