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12 Abnormally high levels of the neurofilament light chain protein in blood, a biomarker of damaged neurons, were found to start an average of 22 years before the median estimated age of symptom onset
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What the Research Actually Shows Published research on AOD-9604 describes: Modest body fat reduction in preclinical and early clinical settings Reduced triglycerides in some studies Minimal effect on IGF-1 confirmed across the clinical dataset Good tolerability adverse event rates in the phase 2 obesity trials were comparable to placebo Variable weight loss some patients respond better than others, consistent with many metabolic interventions The effect size in phase 2 obesity trials was modest typically in the range of a few pounds over the study period
In July 2023, while taping a show about obesity with a panel of experts, she had what she now calls an aha moment. It flipped everything she thought she knew about her own body
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