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In clinical trials, patients treated with GLP-1 injections lost an average of 12.4%17.8% more body weight than the placebo group over the course of a year

Creatine and semaglutide can be combined safely in most people with normal kidney function, but requires intentional hydration (810 glasses daily) and baseline kidney testing

Consistent dosing and commitment to lifestyle changes are crucial for experiencing the full extent of benefits offered by these medications in managing obesity

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As this data is based on a simulation, not a patient-cohort or randomised clinical trial, the authors stressed its limitations