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Non-invasive approaches such as TMS have also shown therapeutic effect but remain underexplored 31 , possibly due to the lack of precise targets in the cortex 25

24 Therefore, considering that GLP-1R is widely distributed in the body, that COPD and diabetes interact with each other and share common pathogenic mechanisms, and that GLP-1 and its receptor agonists have been widely used in diabetic patients and have demonstrated hypoglycemic, pro-inflammatory and anti-inflammatory factors, oxidative stress, neurogenesis and vascular protection, 33 then GLP-1 and its receptor agonists also have a role to play in COPD patients

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doi:10.2337/dc25-0690

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This change might signal a health issue, like reduced blood flow or oxygenation