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In addition, previous studies have shown that ferroptosis and pyroptosis are also associated with granulosa cell death in polycystic ovarian syndrome (PCOS) and diminished ovarian reserve (DOR) ( Gpx4 ), Solute Carrier Family 7 Member 11 ( Slc7a11 ), Acyl-CoA Synthetase Long Chain Family Member 4 ( Acsl4 ), Lysophosphatidylcholine Acyltransferase 3 ( Lpcat3 ) , Apoptosis Inducing Factor Mitochondria Associated 2 ( Aifm2 ), and GTP Cyclohydrolase 1 ( Gch1 ), and the pyroptosis-related genes, including Caspase 1 ( Casp1 ), Caspase 11 ( Casp11 ) , Gasdermin D ( Gsdmd ), and Gasdermin E ( Gsdme ), were analyzed by qPCR
(2013) 20(30):367792 doi: 10.2174/0929867311320999165 126 ErejuwaOOSulaimanSAAb WahabMS
No changes in the concentrations of these amino acids were instead observed in conditioned media (data not shown)
Furthermore, the relative roles of innate cytotoxic mechanisms versus the orchestration of adaptive CD8 + T cell responses across different disease stages remain unclear
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