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Concurrent Improvement in Both Binge Eating and Depressive Symptoms with Naltrexone/Bupropion Therapy in Overweight or Obese Subjects with Major Depressive Disorder in an Open-Label, Uncontrolled Study A 24-week trial of naltrexone ER/bupropion ER in 25 women with MDD and overweight/obesity found significant improvements in binge eating behavior, with 83% reporting minimal issues by week 24

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Treatment of obesity by moderate and severe caloric restriction