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Absorption across the gut epithelium, first-pass liver metabolism, and systemic distribution are all separate steps that determine whether an orally administered compound reaches target tissues at meaningful concentrations

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In a pilot trial, DFP orally administered 15 mg/kg twice daily showed reduced iron deposition in the globus pallidus in patients with pantothenate kinase-associated neurodegeneration (PKAN), a rare disease characterized by neurodegeneration with brain iron accumulation (NBIA) (Abbruzzese et al., 2011)