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Activating GLP-1, GIP, and glucagon receptors simultaneously puts more stress on the gastrointestinal system during the adaptation period

The process of freezing and thawing can destroy the fragile molecular structure, similar to the damage caused by shaking

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30 Among the pathways activated by IR and IGF-1R signaling are the RASRAFMEK1/2extracellular signal-regulated kinase (ERK)-1/2 pathway 34 and the phosphatidylinositol-3-kinase (PI3K)AKTmammalian target of rapamycin (mTOR) pathway, two fundamental pathways for tumor cell proliferation and survival (Figure 2)

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