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In B cells, basal G6PD expression and activity are low, suppressed by transcription factors paired box protein 5 (PAX5) and Ikaros family zinc finger protein 1 (IKZF1)

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Tirzepatide treatment with 5, 10, and 15 mg effectively modulated the activation of protein kinase A (PKA) and the exchange protein directly activated by cAMP (EPAC), thereby promoting the exocytosis of insulin-containing vesicles

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