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It downregulates ten-eleven-translocation protein 3 (TET3) and impairs the DNA demethylation at the paternal alleles of several insulin secretion genes such as glucokinase (GCK), thus making the offspring susceptible to impaired glucose tolerance and diabetes
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doi:10.1002/open.201200014 32
Tirzepatide, a newer medication, is a dual agonist since it acts on both the GLP-1 and glucose-dependent insulinotropic polypeptide receptors
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