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Regulatory reviews classify it as a non-sensitizer and mild-to-non-irritant

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\Potentially Lower Risk: May carry a lower theoretical risk of abnormal cell growth compared to direct GH injections because it works within the body's natural feedback limits

doi: 10.1530/JOE-13-0393 72 YanHYangWZhouFLiXPanQShenZet al

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Tuttle KR, Bakris GL, Bilous RW, Chiang JL, de Boer IH, Goldstein-Fuchs J, Hirsch IB, Kalantar-Zadeh K, Narva AS, Navaneethan SD, Neumiller JJ, Patel UD, Ratner RE, Whaley-Connell AT, Molitch ME