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10.1016/j.cmet.2015.08.001 29 KenakinT

Cena H, Calder PC

Angiotensin Type-1 receptor blockade with losartan increases insulin sensitivity and improves glucose homeostasis in subjects with Type-2 diabetes and nephropathy Nephrol Dial Transplant

And how much do you actually need

After another half-life period, you're down to a quarter of the original amount, and so on