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It works through inhibition of the TREK-1 potassium channel, a mechanism that enhances neuronal excitability and promotes serotonergic transmission

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They're also great for fighting inflammation, says Perricone

If the numbness travels toward your toes as well, you may want to read our guide to a numb big toe

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Whether you are battling deep-set wrinkles or early fine lines, understanding the science behind these ingredients is crucial