"Constipation from GLP-1s can be compounded by the fact that people are eating less," says Hamilton, "resulting often in less fiber consumption and less stool bulk overall." Many people also drink less fluid to avoid feeling overly full on GLP-1 medications, which can also lead to constipation
Liraglutide and dulaglutide therapy in addition to SGLT-2 inhibitor and metformin treatment in Indian type 2 diabetics: a real world retrospective observational study
Without insurance, few people can afford to take a GLP-1 RA
Specifically, first-year discontinuation rates are about 45% for patients with T2DM and 65% for those without (Rodriguez et al., 2025)
As a result Novo Nordisk and the National Institutes of Health funded a randomised, double-blind, controlled trial to look at the issue
The book even goes so far as to outline recipes for transitioning off of the medication, which can be a time when extra guidance is needed