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NNMT catalyzes the methylation of nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine
Medically reviewed by: Jayden Lee, PharmD, EMBA Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes
Daily high doses of B12 may not likely cause harm in most people, but extremely high doses should possibly be avoided unless a healthcare professional prescribes it
Bacterial contamination can cause serious infections, so treat every step as if it matters for preventing harm
Some weight regain is likely but not allespecially if you've maintained muscle and built real habits
Here is what the research tells us about its mechanisms
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