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The Mediterranean diet is positively associated with maintaining kidney function, improving the cardiometabolic profile, and reducing mortality risk in individuals diagnosed with CKD

The association is specific to NAION

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And also, to understand the role of purinergic signaling and adenosine signaling on osteoclast differentiation quantitative PCR analysis was done to estimate the change in the expression of these markers in macrophages

Nat Rev Urol (2018) 15(5):27186

Dosing is personalised based on treatment goals, HbA1c levels, body weight, renal function, concurrent medications, and tolerability