The specific glycyl-L-histidyl-L-lysine sequence with a copper 2+ complex is what has 50 years of peer-reviewed support behind it
Pharmacokinetic studies in rodents have documented rapid absorption following subcutaneous injection (Tmax approximately 30 minutes), with distribution to multiple tissues including liver, kidney, skin, and lung
Finally, partial inhibition of GSH may induce stress responses in cancer cells, leading to the upregulation of detoxifying enzymes and drug resistance
Compared to molecules that are randomly distributed in the cytoplasm, drug molecules concentrated in subcellular compartments are more difficult to excrete, which improves the bioavailability of drugs while reducing the development of drug resistance [82, 83]
others remain experimental and require individualized supervision
You can read the who-and-how in this New York Times article