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10.1080/01480545.2018.1463239 Drug Chem Toxicol

The Set-Point Model A metallosensor is a single-component signal transduction system, in that inducer sensing and regulation of gene expression occurs within the same polypeptide chain

The peptide sequence incorporates critical modifications to native human amylin: an N-terminal lipidation with eicosanedioic acid conjugated through a gamma-glutamic acid linker, strategic proline substitutions to prevent fibril formation, and an amidated C-terminus to enhance receptor binding