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Additionally, it was also discovered that IgE-mediated mast cell activation as well as mast cell-derived tryptase play a pathogenic role in the development of osteoarthritis (Wang et al., 2019)

It is worth noting that the tumors only increased by 2.76 times even using the DOX/LAAM GSH-CQDs at 2 mg kg 1 , which still showed a better treatment effect than the DOX and Doxil groups

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