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The researchers noted tolerability issues with twice-daily intraperitoneal injections in ob/ob mice (necessitating shortened treatment duration), but this reflected injection stress rather than compound toxicity

HOMA2 (updated HOMA model which took account of variations in hepatic and peripheral glucose resistance), homeostatic Model Assessment for IR (HOMA-IR), the oral glucose insulin sensitivity index (OGSI), fasting Insulin (FINS), and fasting plasma glucose (FPG) based on fasting glucose and insulin levels 439,440,441,442,443 are widely utilized IR measurements in clinical research