The SURMOUNT trials showed tirzepatide producing average weight loss of 20 to 22.5 percent at the highest dose over 72 weeks, compared to semaglutide 14.9 percent in STEP 1
Retatrutide improves it through GLP-1 and GIP signaling at the pancreas
Same 0.5 mg of semaglutide in all three cases
Protein preserves muscle, maintains metabolic rate, and improves satiety, amplifying the appetite suppression already provided by semaglutide
Key takeaways Liraglutide is the active ingredient in the brand-name GLP-1 medications Saxenda and Victoza, while semaglutide is the active ingredient in Ozempic, Wegovy, and Rybelsus
If you have insurance, Rybelsus is usually one of the cheapest weight loss medications you can get