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doi: 10.1016/0003-9861(90)90635-C 33 HalliwellB

The total protein content was determined with BCA protein assay (TaKaRa, Shiga, Japan)

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The mechanisms contributing to this combination's efficacy may include central potentiation of hypothalamic interleukin-6 (IL-6) activity enabling post-leptin receptor potentiation of leptin action, as genetic or pharmacological interruption of IL-6 action attenuates the weight loss activity of amylin in mice [16]

As such, in a headtohead study with lixisenatide and liraglutide, the shorteracting agent lixisenatide produced a modest, transient 13 beat per minute increase in HR, whilst the longer acting GLP1 mimetic liraglutide was associated with a more distinct and sustained 610 beats per minute elevation (Meier et al., 2015)