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Science (2005) 308(5729):18014

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Once activated, caspase-3 initiates the cleavage of a downstream substrate, such as nuclear poly (ADP-ribose) polymerase (PARP), which facilitates cellular disassembly and serves as a biomarker of cell apoptosis

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If f(x)0 for all x(a,b),then the function f(x) is convex upward (or concave downward) on the interval