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PMID: 36118519 Kaohsiung J Med Sci Dihydroartemisinin enhances gefitinib cytotoxicity against lung adenocarcinoma cells by inducing ROS-dependent apoptosis and ferroptosis

When NSBSO is reduced by GSH, the disulfide bond of NSBSO will break and NSBSO will then be converted to Nap- D F D FY-thiol and this process can be detected by liquid chromatography-mass spectrometry (LCMS) analysis (Additional file 1: Fig

[5] The precise numeric half-life in a human being is unknown, and any specific figure presented as established human pharmacokinetics is not evidence-based

Pharmacokinetics and Metabolism of Natural Methylxanthines in Animal and Man

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13 GSH is synthesized via a two-step enzymatic pathway and can be regenerated from GSSG by GSH reductase using NADPH