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Overactivation of LEPR might increase the levels of Cdc42, which is directly related to the secretion of insulin granules, as well as the activation of Cdc42 through the MEK/ERK/NeuroD1 axis, which induces insulin expression

3A, B, Sirt3 expression was increased in microglia at 3 days after ICH as compared to Sham groups, which further increased in ICH + IF group (sham 8.35 2.24 vs

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Experimental studies also suggest direct retinal effects, such as restoring blood-retinal barrier integrity and preventing retinal cell death

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