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These observations are consistent with those from similar post-hoc analyses of patients receiving glucose-lowering background medication in the clinical trial programme for once-weekly subcutaneous semaglutide (SUSTAIN 24 and 10) [17]

Tirzepatide patents extend into the early-to-mid 2030s, and peptide medicines typically follow the biosimilar route rather than standard generic approval

Whether GLP-1RAs simply engage CNS GLP-1Rs accessible via circumventricular organs or are actively transported to brain regions via GLP-1Rs within the blood brain barrier, such as those expressed in tanycytes [84], remains a topic of ongoing investigation (Fig

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