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Cellular efflux is the probable reason for the presence of thiamine in plasma and cerebrospinal fluid [175-177].Thiamine in the glomerular filtrate is reabsorbed by the renal brush border membrane high affinity transporters where influx is increased by an outward directed H+gradient [178] RFC-1 is expressed on the apical and basolateral surface of the proximal tubular epithelial cells [179]

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Genetic analyses showed that MORF2 negatively regulates basic immunity and resistance to pathogens