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Compounding pharmacies, outsourcing facilities and telehealth prescribers should carefully review their GLP-1 compounding operations, documentation practices and prescriber significant difference determinations in light of this restated guidance

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The 24.2% figure from Phase 2 trials represents an average across all participants in the 12mg group

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Despite limited clinical evidence exists regarding the comprehensive cardiovascular impacts of concurrent treatment with these agents in patients with T2D 18,19,20 , and preclinical studies suggest potential synergistic effects for MASLD 17 , there is a critical need for robust clinical research to evaluate the effect of combined SGLT2is and GLP-1RAs in patients with MASLD