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Pharmacological GLP-1RA Action Key Mechanistic Distinctions A comprehensive review published in Cell Metabolism reviewed circuits engaged by endogenous versus pharmacological GLP-1 action, highlighting key GLP-1R-positive cell types and pathways transducing metabolic and non-glycaemic GLP-1 signals

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Finally, the panel posited that as IL-23 inhibitors may be able to limit establishment of IL-17/IL-22 memory cells responsible for relapses in psoriasis, trials are needed focussing on early stage treatment