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Tirzepatide's dual activation may produce synergistic effects in some patients, but semaglutide's single-pathway focus remains highly effective for many individuals, especially those with certain genetic profiles

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However, the recent study on semaglutide, titled Ischemic optic neuropathy with semaglutide: global observational analysis of sex- and formulation-specific risk, published in the British Journal of Ophthalmology (BJO), shows that those using Wegovy are at greater risk of developing no-artertic ischemic optic neuropathy (Naion) than Ozempic