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Producers refine WPC into

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Blood pressure reactivity to stress (cold pressor test) was significantly attenuated in the combination group compared to both placebo and L-citrulline alone

Additionally, clearance of these particles from the bloodstream (via the liver and spleen) is inversely related to size: the smallest particles circulate the longest, increasing the likelihood of absorption at their target tissues

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L-Ornithine is distinct from L-Arginine and L-Citrulline as it is not involved with nitric oxide production, but L-Ornithine buffers ammonia reducing fatigue associated with exercise