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In mice, the benefits of FOXO4-DRI continued to develop after the treatment period ended, as tissue remodeling and functional recovery are ongoing processes (Baar et al., 2017)

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doi: 10.1208/s12248-015-9719-7

Further, overproduction of free radicals have also been shown to occur due to spontaneous breakdown (autoxidation) and/or excessive metabolism by monoamine oxidase of adrenaline, noradrenaline and dopamine, which can further overwhelm the brains antioxidant systems (Cohen, 1984

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