Given its high usage and availability as an over-the-counter analgesic, a systematic review of paracetamols efficacy and tolerability in individual conditions is warranted ( On the whole, although there is no direct evidence in COVID-19 patients, PAC is likely to promote GSH depletion, especially in those population groups at higher risk ( The following considerations further strengthen the criticism toward the use of PAC as a safer alternative to NSAID: PAC has been preferred to NSAIDs and steroids for the symptomatic and domiciliary management of the early stages of COVID-19, a choice grounded of the precautionary principle (but still theoretical in this specific case) principle primum non nocere ( Counterintuitively, however, the same precautionary principle has not been applied to PAC itself, and the risks of developing severe COVID-19 associated to the reduction of GSH might be far higher than the benefits derived from discouraging the use of NSAIDs or steroids

Transl Psychiatry 12 , 464 (2022)
The prescription must be directed to a participating pharmacy enrolled in the Bridge program
Bisdemethoxycurcumin attenuated renal injury via activation of Keap1/Nrf2 pathway in high-fat diet-fed mice
J Trace Elem Med Bio
Zhang B, Zhou WJ, Gu CJ, et al