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Monthly during use: Self-examine all moles using the ABCDE criteria: - A symmetry: One half does not match the other - B order: Edges are irregular, ragged, or blurred - C olor: Uneven color with shades of brown, black, red, white, or blue - D iameter: Larger than 6 mm (the size of a pencil eraser) - E volving: Any change in size, shape, color, elevation, or any new symptom (bleeding, itching, crusting) 3

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The microbiota-gut-brain axis thus represents a complex communication network that integrates microbial, immune, endocrine, and neural signaling to maintain homeostasis

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