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The terminal arginine is removed by a processing reaction in the late-Golgi compartment and the HDEL sequence is then accessible for interaction with the HDEL receptor in the target cell

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In fact, one survey of 701 patients with OCD symptoms found that an average of 10.2 years elapsed between the onset of OCD symptoms and the first attempt to obtain professional help, and an average of 7 additional years elapsed before the patients received effective treatment (Hollander 1997)