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10.3389/fphar.2021.731609 162 WangY.HanY.ShangS.XiaoJ.TaoL.PengZ.et al (2024b)

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2009 Dec 10;52(23):7788-99

Cross-age comparisons show that the genetic structures of pediatric and elderly IBD exhibit a bipolar differentiation VEO-IBD has the heaviest genetic burden: more than one-third of those with onset before age 6 carry single-gene defects, IL-10R mutations can be cured through hematopoietic stem cell transplantation [203,204,205], NOD2 biallelic mutations often lead to stricturing CD and high surgery rates [206],and rare defects such as lipopolysaccharide-responsive beige-like anchor protein (LRBA) and syntaxin-binding protein 2 (STXBP2) are also frequently observed [206, 207]

2631 Although metabolic-related factors may be moderational in some persons and select conditions, they do not fully explain the improvements reported in psychopathology

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