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It protects against excitotoxicity, an aspect that would be interesting since it has been observed that the increase in intracellular ROS levels is related to damage in the cell membrane, impaired calcium homeostasis (Thibault et al., 2007

A recent study has demonstrated that an acute increase in the intracellular concentration of ROS inhibits the glycolytic enzyme pyruvate kinase M2 (PKM2) through the oxidation of Cys358 ( NRF2 INHIBITORS FOR ANTICANCER THERAPY Due to the multifaceted roles of Nrf2 in cancers, Nrf2 inhibitors could be effective for anticancer therapy

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Theoretical concerns include overlapping effects with growth hormone, recombinant IGF-1, anabolic steroids, insulin or glucose-lowering drugs, and other peptide therapies affecting growth, glucose, or tissue signaling [7] [19]

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