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For constipation codes, the K59 sub-codes were last significantly revised with the addition of K59.03 (drug-induced) and K59.04 (chronic idiopathic) in the mid-2010s

The evidence points to the involvement of NO in several features of the disease, such as bloodbrain barrier disruption, oligodendrocyte damage and demyelination, axonal degeneration, and loss of function as a result of reduced axonal conduction

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Sulfide oxidation promotes hypoxic angiogenesis and neovascularization

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