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Supporting tissue repair may help promote recovery

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A link to vitamin A deficiency also has been noted

That leaves developers in a Catch-22 situation

Long-term use: Continuous use could lead to sustained collagen production, maintained skin hydration, less visible wrinkles, and better overall skin health

For OTA, the Klaassen equation has been used to estimate the continuous exposure to OTA based on blood plasma concentrations, and assumptions for plasma clearance and bioavailability (details in Duarte et al