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This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme
Furthermore, melatonin reduces the expression of pro-inflammatory genes by blocking the toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/NF-B signaling pathway, which plays a key role in inflammatory signal transduction in glial cells
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Figure 20-3 The formation of mediators important in the pathogenesis of respiratory disease
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