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Acknowledgements This research was supported by National Key R&D Program of China (2021YFF0702600), the National Natural Science Foundation of China (82222056 and 82111530099), Guangdong Special Young Talent Plan of Scientific and Technological Innovation (2019TQ05Y510), the Natural Science Foundation of Guangdong (2022A1515012316), the Guangdong International Joint Research Program (2020A0505100027), and National Key Clinical Discipline